Methods of detecting and controlling mucoid Pseudomonas biofilm production
US8399649B2 · kind B2 · utility
2Cited by
10References
12Claims
0Family size
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Key dates
| Filing date | Jun 21, 2010 |
| Grant date | Mar 19, 2013 |
| Priority date | — |
| Expiry date | Dec 14, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/143333
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Compositions and methods for detecting and controlling the conversion to mucoidy in Pseudomonas aeruginosa are disclosed. The present invention provides for detecting the switch from nonmucoid to mucoid state of P. aeruginosa by measuring mucE expression or MucE protein levels. The interaction between MucE and AlgW controls the switch to mucoidy in wild type P. aeruginosa. Also disclosed is an alginate biosynthesis heterologous expression system for use in screening candidate substances that inhibit conversion to mucoidy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.