Process and methods for the preparation of optically active cis-2-hydroxymethyl-4-(cytosin-1′-yl)-1,3-oxathiolane or pharmaceutically acceptable salts thereof
US8399655B2 · kind B2 · utility
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44Claims
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Key dates
| Filing date | Jun 22, 2011 |
| Grant date | Mar 19, 2013 |
| Priority date | — |
| Expiry date | Jul 7, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65586
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is provided a method for resolving a compound of formula III, in the cis configuration:There is also provided a process for producing optically active compound of formula I or II:wherein: R1, R2, R3 are as defined herein, the method and process involving the production, recovery and conversion of diastereomeric salts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.