Salt of 1,3,5-triazine-2,4,6-triamine derivative

US8399663B2 · kind B2 · utility

Assignee

• ASTELLAS PHARMA INC. · JP

Inventors

• Junya Ohmori · Tsukuba, JP
• Makoto Kasai · Maebashi, JP
• Takenori Kimura · Takahagi, JP
• Noritaka Hamada · Tokyo, JP
• Ryo Mizoguchi · Tokyo, JP
• Satoshi Miyamoto · Tokyo, JP
• Noriyuki Kawano · Tsukuba, JP

Key dates

• Filing date: Apr 2, 2010
• Grant date: Mar 19, 2013
• Expiry date: Jun 16, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Anytime obtained is uniform crystal of N-(4-fluorophenyl)-N′-phenyl-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound A) and/or N,N′-bis (4-fluorophenyl)-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound B) as a medicament or a starting material for the preparation of the medicament, and provided are a fumarate of the compound A and/or the compound B having excellent stability and a novel crystal thereof. A salt of the compound A and/or the compound B with fumaric acid enables uniform crystal to be anytime obtained, and thus, it is a compound that is very useful as a medicament or a starting material for the preparation of the medicament having excellent stability.