Antibody design using anti-lipid antibody crystal structures
US8401799B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Jun 4, 2010 |
| Grant date | Mar 19, 2013 |
| Priority date | — |
| Expiry date | Jun 4, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2405/08
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods for designing optimized antibodies, including optimized humainized or human antibodies, to target bioactive lipids are provided. These methods may be performed in silico and may be intended to enhance binding affinity of an antibody to its original target lipid, and/or to alter binding specificity. Antibodies produced by these methods are also provided, as are methods for using them.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.