Dendritic chelated compounds, methods for making the same and pharmaceutical compositions containing the same
US8404216B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 9, 2007 |
| Grant date | Mar 26, 2013 |
| Priority date | — |
| Expiry date | Nov 21, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G83/002
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to dendritic chelated compounds, to methods for producing the same and to pharmaceutical compositions containing the same. The dendritic chelated complexes of the present invention have the following formula (I): [[MC]En-[D]m-X1p1X2p2X3p3X4p4]z−zB+ (I), where m is a magnetic or scintigraphic marker, C is a chelating agent of the marker M, E is a spacer, n=0 or 1, D is compound capable of forming a dendritic structure, m is an integer equal to 1 or 2 or 4, X1 is a group increasing the complex lipophily, p1 is an integer from 0 to 12, X2 is a group increasing the complex specificity for a particular organ, p2 is an integer equal to 1 or 2 or 4, X3 is a group having a therapeutic activity, p3 is an integer equal to 0, 1, 2 or 4, X4 is a CH3 group, p4 is an integer from 0 to 12, B is a counter-ion, z is an integer equal to 0, 1, 2, 3 or 4. The invention can be used in the field of pharmacy, more precisely in medical imaging.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.