Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof

US8404459B2 · kind B2 · utility

Assignee

• BioArctic Neruoscience AB · SE

Inventors

• Pär Gellerfors · Lidingö, SE
• Lars Lannfelt · Stockholm, SE

Key dates

• Filing date: Dec 23, 2011
• Grant date: Mar 26, 2013
• Expiry date: Dec 23, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/387
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention pertains to a method of measuring Aβ protofibrils in a sample. The method includes the steps of (a) providing a labeled monoclonal antibody or fragment thereof that binds wildtype Aβ 42/40 protofibril and Aβ42/40 Arc protofibril and has no or little cross-reactivity to Aβ 42/40 monomers with an agent that generates a measurable signal, (b) contacting said labeled antibody or fragment thereof with the fluid or tissue having or suspected of comprising Aβ protofibrils, and (c) measuring the amount of protofibrils bound to the antibody by measuring the signal generated by the agent.