Heterosubstituted N-thiolated beta-lactam compounds and methods of use
US8404671B2 · kind B2 · utility
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4References
45Claims
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Key dates
| Filing date | Nov 22, 2010 |
| Grant date | Mar 26, 2013 |
| Priority date | — |
| Expiry date | Nov 22, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/48
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to heterosubstituted N-thiolated beta-lactams, compositions comprising these compounds, methods for their production, and methods of use as antibiotics to inhibit the growth of bacteria. In one embodiment, the compounds have the structure shown in formula (A) or formula (B) or formula (C):wherein the R groups are as defined in the specification. The antibacterial agents of the invention can be administered to a human or animal to treat or inhibit bacterial infection, such as that of Staphylococcus species, including methicillin-resistant Staphylococcus aureus (MRSA).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.