Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors

US8404685B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Dieter Dorsch · Ober-Ramstadt, DE
• Oliver Schadt · Rodenbach, DE
• Frank Stieber · Heidelberg, DE
• Andree Blaukat · Heilbad Heiligenstadt, DE

Key dates

• Filing date: Apr 24, 2009
• Grant date: Mar 26, 2013
• Expiry date: Jul 20, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I, in which R1, R2, R3, R3′, R4 and D have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumors.