Aurora kinase modulators and method of use
US8404694B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 19, 2009 |
| Grant date | Mar 26, 2013 |
| Priority date | — |
| Expiry date | Apr 9, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to chemical compounds having a general formula Iwherein A1-5 and 7-8, D′, L1, L2, R1, R3, R6-8, n and o are defined herein, and synthetic intermediates, which are capable of modulating the activity of Aurora kinase proteins and, thereby, influencing various disease states and conditions related to the activities of Aurora kinases. For example, the compounds are capable of influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.