Spirocyclic cyclohexane compounds

US8404740B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Stefan Schunk · Aachen, DE
• Saskia Zemolka · Aachen, DE
• Derek Saunders · Aachen, DE
• Michael Gruss · Aachen, DE
• Heinz Graubaum · Berlin, DE

Key dates

• Filing date: Aug 21, 2009
• Grant date: Mar 26, 2013
• Expiry date: Oct 22, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Spirocyclic cyclohexane compounds corresponding to formula IIn which R1, R2, R3 and R5 through R10 and X have defined meanings, a process for their preparation, pharmaceutical compositions containing such compounds, and the use of such spirocyclic cyclohexane compounds in the treatment and/or inhibition of pain and other conditions mediated by the ORL-1 or the μ-opioid receptor.