Chiral phosphorus compound

US8404843B2 · kind B2 · utility

Assignee

• Johnson Matthey Public Limited Company · GB

Inventors

• Brian Adger
• Alan Dyke · London, GB
• Giancarlo Francio · Nùgoro/Nuoro, IT
• Frederick Ernest Hancock · Springtown, GB
• Walter Leitner · Aachen, DE
• Thomas Pullmann · Aachen, DE
• Andreas Seger · Soham, GB
• Antonio Zanotti-Gerosa · Cambridge, GB

Key dates

• Filing date: Jun 25, 2012
• Grant date: Mar 26, 2013
• Expiry date: Jun 25, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F15/0073
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel chiral phosphorus compounds which can be readily prepared from quinoline derivatives as inexpensive starting compounds and have the general formula (I)wherein R1, R2, R3, R4, R5 are chiral or achiral organic residues which are derived from substituted or unsubstituted straight or branched chain or cyclic aliphatic or aromatic groups and which, in the case of the pairs R1/R2 and R4/R5, may be interconnected. Further, the invention relates to methods for the synthesis of chiral phosphorus compounds of general formula (I) and their use as catalyst components in processes for the preparation of optically active products.