(20R,25S)-2-Methylene-19,26-Dinor-1α,25-Dihydroxyvitamin D3 in crystalline form
US8404874B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 28, 2011 |
| Grant date | Mar 26, 2013 |
| Priority date | — |
| Expiry date | Oct 17, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of purifying (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 to obtain (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 in crystalline form. The method includes the steps of preparing a solvent of methanol and water, dissolving a product containing (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 crystals, and recovering the (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 crystals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.