Patent · US Active

Taxane analogs for the treatment of brain cancer

US8409574B2 · kind B2 · utility

0Cited by

4References

12Claims

0Family size

Inventors

James D. McChesney · Etta, US
Gilles H. Tapolsky · Louisville, US
David E. Emerson · Longmont, US
John Marshall · Somerville, US
Tauseef Ahmed · Hawthorne, US
Allen Cohn · Denver, US
Michael Kurman · Upper Saddle River, US
Manuel Modiano · Tucson, US

Key dates

Filing date	Aug 20, 2010
Grant date	Apr 2, 2013
Priority date	—
Expiry date	Aug 20, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D493/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a substrate for MDR protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.