Crystal structure of glutaminyl cyclase

US8409837B2 · kind B2 · utility

Assignee

• PROBIODRUG AG · DE

Inventors

• Stephan Schilling · Halle (Saale), DE
• Jens-Ulrich Rahfeld · Lieskau, DE
• Birgit Koch
• Michael Wermann · Halle (Saale), DE
• Christoph Parthier · Halle (Saale), DE
• David Ruiz-Carillo · Singapore, SG
• Milton T. Stubbs · Halle (Saale), DE

Key dates

• Filing date: Aug 19, 2011
• Grant date: Apr 2, 2013
• Expiry date: Aug 19, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G16C20/50
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A novel crystal structures of human and murine glutaminyl cyclase (QC, EC 2.3.2.5), methods of preparing the crystals, as well as the use of said crystal structures for identifying inhibitors of human and murine glutaminyl cyclase.