Mannich base N-oxide drugs

US8410075B2 · kind B2 · utility

Assignee

• CASCADE PRODRUG INC. · US

Inventors

• John F. W. Keana · Eugene, US
• Paul B. Westberg · San Mateo, US
• John G. Curd · Hillsborough, US
• Alshad S. Lalani · Briarcliff Manor, US

Key dates

• Filing date: Sep 21, 2009
• Grant date: Apr 2, 2013
• Expiry date: Apr 16, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are Mannich base N-oxides of drugs containing acidic N—H groups. Pharmaceutical compositions comprising a therapeutically effective amount of Mannich base N-oxides, or a N-oxide rearrangement product, pharmaceutically acceptable salt or prodrug thereof, are also disclosed. Further, disclosed are methods of using the compounds, alone or in combination with one or more other active agents or treatments.