Patent · US Active

Composition and methods to treat cardiac diseases

US8410078B2 · kind B2 · utility

8Cited by

5References

14Claims

0Family size

Assignee

UNIVERSITY OF CONNECTICUT · US

Inventors

Bruce Liang · Avon, US
Achilles Pappano · West Simsbury, US
Jian Shen · Shanghai, CN

Key dates

Filing date	May 22, 2007
Grant date	Apr 2, 2013
Priority date	—
Expiry date	Jan 14, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P9/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are N-methanocarba derivatives of AMP and their use in the treatment of cardiac and vascular diseases and conditions responsive to activation of the cardiac P2X receptor. In one embodiment, the N-methanocarba derivative of AMP is the N-methanocarba derivative of 2-chloro-AMP. Diseases and conditions responsive to activation of the cardiac P2X receptor include, for example, cardiac hypertrophy, cardiac failure resulting from any cause of abnormal Ca2+ homeostasis or from myocardial injuries, vascular insufficiency leading to myocardial infarction, post-myocardial infarction conditions, post-myocardial infarction conditions within the short-term post-infarction period, and diastolic heart failure.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.