Phospholipid compositions and uses thereof
US8410085B2 · kind B2 · utility
2Cited by
0References
6Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 17, 2008 |
| Grant date | Apr 2, 2013 |
| Priority date | — |
| Expiry date | Sep 1, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P3/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
We have discovered that phospholipids diundecanoyl (C11:0-C11:0) and dilauroyl (C12:0-C12:0) phosphatidylcholine (PC) act as agonists of the LRH-1 receptor. We have also shown that administration of these lipids to diabetic mice reduces blood glucose levels. On the basis of these discoveries, the present invention features compositions that include these lipids and structurally related lipids. Also featured are methods of treating metabolic disorders and inflammatory bowel disease, lowering blood glucose levels, and increasing LRH-1 receptor activity in a subject by administration of these lipids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.