Cycloalkyl substituted pyrimidinediamine compounds and their uses

US8410093B2 · kind B2 · utility

Assignee

• Rigel Pharmaceuticals, Inc. · US

Inventors

• Hui Li · Santa Clara, US
• Ankush Argade · Foster City, US
• Rajinder Singh · Belmont, US
• Sambaiah Thota · Fremont, US
• David Carroll · San Francisco, US
• Kin Tso · San Francisco, US
• Vanessa Taylor · San Francisco, US
• John McLaughlin · Media, US
• Vadim Markovtsov · San Mateo, US

Key dates

• Filing date: Nov 22, 2010
• Grant date: Apr 2, 2013
• Expiry date: Dec 5, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.