Prodrugs of a piperidinyl derivative as modulators of chemokine receptor activity

US8410139B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• John Hynes · Washington Crossing, US
• Percy H. Carter · Princeton, US
• Lyndon A. M. Cornelius · Jackson, US
• T.G. Murali Dhar · Carbondale, US
• John V. Duncia · Newtown, US
• Satheesh Kesavan Nair · Kanchinakote, IN
• Joseph B. Santella · Springfield, US
• Jayakumar Sankara Warrier · Bengaluru, IN
• Hong Wu · Meekrap-oord, CN

Key dates

• Filing date: Oct 4, 2010
• Grant date: Apr 2, 2013
• Expiry date: Mar 1, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/59
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application describes prodrugs of the compound of formula (I):or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis using the prodrug compounds of the invention are disclosed.