Methylene urea derivatives

US8410143B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Hans-Peter Buchstaller · Griesheim, DE
• Matthias Wiesner · Seeheim-Jugenheim, DE
• Oliver Schadt · Rodenbach, DE
• Christiane Amendt · Mühltal, DE
• Frank Zenke · Darmstadt, DE
• Christian Sirrenberg · Darmstadt, DE
• Matthias Grell · Darmstadt, DE
• Dirk Finsinger · Darmstadt, DE

Key dates

• Filing date: Jun 19, 2009
• Grant date: Apr 2, 2013
• Expiry date: Jan 17, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.