Patent · US Active

Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors

US8410163B2 · kind B2 · utility

0Cited by

0References

13Claims

0Family size

Assignee

Telik, Inc. · US

Inventors

Paul Powell Beroza · Belmont, US
Komath V. Damodaran · Cupertino, US
Stella Lui · Daly City, US
Wenli Ma · Union City, US
Zhuo Wang · Fremont, US
Hua Xu · Sunnyvale, US

Key dates

Filing date	Feb 9, 2010
Grant date	Apr 2, 2013
Priority date	—
Expiry date	Feb 9, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D409/12
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides and their salts are tubulin polymerization inhibitors, useful in the treatment of cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.