Antibody against calcified globule and use of the same
US8410251B2 · kind B2 · utility
12Cited by
1References
16Claims
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Key dates
| Filing date | Mar 9, 2009 |
| Grant date | Apr 2, 2013 |
| Priority date | — |
| Expiry date | Mar 9, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/323
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present inventors carried out immunization using renal/urinary calculus-derived calcified globules or carotid artery-derived arteriosclerotic plaques, and then obtained antibodies specific to calcified globules (NLO) via screening with NLO. The present inventors demonstrated that the antibodies reacted specifically to arteriosclerotic lesions (calcified lesions) and visualized arteriosclerotic plaques (in particular, calcified lesions) by using fluorescently labeled antibodies. Accordingly, the present inventors completed the present invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.