Protease inhibitors

US8410300B2 · kind B2 · utility

Assignee

• TaiMed Biologics, Inc. · TW

Inventors

• Brent Richard Stranix · Rue du Bois des Loges, CA
• Jean-Francois Lavallee · Montréal, CA
• Nicolas LeBerre · Montréal, CA
• Valérie Perron · Laval, CA
• Dominik Herbart · Blainville, CA
• Guy Milot · Chapel Hill, US
• Chandra Panchal · London, CA

Key dates

• Filing date: Sep 20, 2007
• Grant date: Apr 2, 2013
• Expiry date: Jan 14, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein R2 may be, for example, 2-pyridyl-CH2—, 3 -pyridyl-CH2—, 4-pyridyl-CH2—, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R2a—CO—, R2a being selected from the group consisting of piperonyl, 2-pyrazinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONR5R6, CH2OH or CH2OR7.