Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents
US8410312B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Aug 11, 2006 |
| Grant date | Apr 2, 2013 |
| Priority date | — |
| Expiry date | Sep 29, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.