Patent · US Active

Microarray-based gene copy number analyses

US8412465B2 · kind B2 · utility

2Cited by

0References

11Claims

0Family size

Assignee

BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY · US

Inventors

Wenjiang Fu · Okemos, US
Yalu Wen · East Lansing, US
Ming Li · Beijing, CN

Key dates

Filing date	Apr 7, 2010
Grant date	Apr 2, 2013
Priority date	—
Expiry date	May 12, 2031

Classification

Technology area (CPC G)Physics
CPC primaryG16B25/00
WIPO fieldComputer technology
WIPO sectorElectrical engineering

Abstract

This invention contemplates an accurate and efficient estimation of gene copy number using oligonucleotide microarrays. The method integrates gene copy number data obtained from perfect match and mismatch probe sequence structure intensities and probe binding affinities. In one embodiment, an accurate determination of single nucleotide polymorphisms (SNPs) sequences is obtained. In another embodiment, an accurate detection and determination of DNA copy number alteration is obtained. In another embodiment, an accurate estimation for RNA gene expression is obtained.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.