Biosensor electrode mediators for regeneration of cofactors
US8414760B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Jul 30, 2012 |
| Grant date | Apr 9, 2013 |
| Priority date | — |
| Expiry date | Jul 30, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T29/49155
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.