Calcium phosphate granules of the hydroxyapatite type, their preparation process and their applications
US8414857B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Dec 11, 2009 |
| Grant date | Apr 9, 2013 |
| Priority date | — |
| Expiry date | Jan 24, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC01B25/327
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns calcium phosphates in granular form having an x-ray diffraction pattern characteristic of hydroxyapatite and good compressibility and flow properties in direct compression applications. The invention also concerns the method for preparing said granules characterized in that it comprises processing a suspension of brushite dicalcium phosphate having a certain particle-size distribution using a basic solution, and maintaining the pH at not less than 7.0 for a sufficient time interval to enable the transformation of the brushite calcium phosphate into hydroxyapatite calcium phosphate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.