Mitigation of photodamage in analytical reactions

US8415128B2 · kind B2 · utility

Assignee

• PACIFIC BIOSCIENCES OF CALIFORNIA, INC. · US

Inventors

• John Eid · San Francisco, US
• Devon Murphy · Mountain View, US
• Geoffrey Otto · Brookline, US
• Stephen Turner · Menlo Park, US

Key dates

• Filing date: Jul 26, 2011
• Grant date: Apr 9, 2013
• Expiry date: Jul 26, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/582
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.