Patent · US Active

Cyclic (aza)indolizinecarboxamides, their preparation and their use as pharmaceuticals

US8415336B2 · kind B2 · utility

4Cited by

1References

11Claims

0Family size

Assignee

Sanofi · FR

Inventors

Henning Steinhagen · Pocking, DE
Bodo Scheiper · Frankfurt am Main, DE
Hans Matter · Langenselbold, DE
Gary MCCORT · Paris, FR
Guillaume BEGIS · Paris, FR
Pascale Goberville · Paris, FR
Bérangère Thiers · Paris, FR

Key dates

Filing date	Jan 19, 2012
Grant date	Apr 9, 2013
Priority date	—
Expiry date	Jan 19, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D487/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to cyclic indolizinecarboxamides and azaindolizinecarboxamides of the formulae Ia and Ib,wherein R, Ra, R10, R20, R30, R40, Y, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formulae Ia and Ib, their use and pharmaceutical compositions comprising them.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.