Substituted benzazoles and methods of their use as inhibitors of RAF Kinase

US8415382B2 · kind B2 · utility

Assignee

• Novartis Vaccines and Diagnostics, Inc. · US

Inventors

• Abran Q. Costales · Corona, US
• Teresa Hansen · Danville, US
• Barry Haskell Levine · Lafayette, US
• Christopher McBride · Oakland, US
• Daniel Poon · Piedmont, US
• Savithri Ramurthy · Walnut Creek, US
• Paul A. Renhowe · Danville, US
• Cynthia Shafer · El Sobrante, US
• Sharadha Subramanian · San Ramon, US
• Joelle Verhagen · Emeryville, US

Key dates

• Filing date: Sep 5, 2008
• Grant date: Apr 9, 2013
• Expiry date: Apr 3, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.