Silk fibroin hydrogels and uses thereof

US8420077B2 · kind B2 · utility

Assignee

• Allergan, Inc. · US

Inventors

• Gregory H. Altman · Arlington, US
• Rebecca L. Horan · Arlington, US
• Adam L. Collette · Westminster, US
• Jingsong Chen · Virginia Beach, US

Key dates

• Filing date: Apr 20, 2010
• Grant date: Apr 16, 2013
• Expiry date: Apr 20, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.