Patent · US Active

Tumor suppressor activating polypeptides and uses thereof

US8420100B2 · kind B2 · utility

0Cited by

1References

2Claims

0Family size

Assignees

Department of Biotechnology · IN
NATIONAL CENTRE FOR CELL SCIENCE · IN

Inventors

Samit Chattopadhyay · Pune, IN
Archana Jalota-Badhwar · Pune, IN

Key dates

Filing date	Sep 10, 2007
Grant date	Apr 16, 2013
Priority date	—
Expiry date	Jul 6, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Chimeric tumor suppressor activating peptides derived from matrix attachment region binding protein (MARBP) SMARI unique in their sequence comprising a arginine rich motif flanked by serine residues wherein from the stretch of four consecutive serine residues the first serine residue gets phosphorylated by the protein kinase C family of serine threonine kinases being indispensable for its functionality, the phosphorylation being directly correlated to the phosphorylation of p53 at serine 15 residue thereby stabilizing it, wherein the peptide activates p53 by modifying it post translationally which allow phosphorylation and translocation of p53 to the nucleus.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.