Method to block the infection by flaviviruses, molecules and uses

US8420311B2 · kind B2 · utility

Assignee

• CENTRO DE INGENIERÍA GENÉTICA Y BIOTECNOLOGÍA · CU

Inventors

• Vivian Huerta Galindo · Boyeros, CU
• Glay Chinea Santiago · Havana, CU
• Noralvis Fleitas Salazar · Havana, CU
• Alejandro Miguel Martin Dunn · Boyeros, CU
• Mónica Sarría Núñez · Havana, CU
• Osmany Guirola Cruz · Boyeros, CU
• Patricia Gabriela Toledo Mayora · Havana, CU
• Aniel Puente · Havana, CU
• Vladimir Armando Perez · Havana, CU
• Osvaldo Reyes Acosta · Havana, CU
• Hilda Elisa Garay Pérez · Boyeros, CU
• Ania Cabrales Rico · Boyeros, CU
• Alexis Musacchio Lasa · Boyeros, CU
• Gabriel Ramon Palomares · Havana, CU
• Luis Javier González López · Boyeros, CU

Key dates

• Filing date: Apr 26, 2007
• Grant date: Apr 16, 2013
• Expiry date: Apr 9, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.