Patent · US Active

Antibodies for the detection of integrin complexes in FFPE material

US8420348B2 · kind B2 · utility

2Cited by

3References

5Claims

0Family size

Assignee

Merck Patent GmbH · DE

Inventors

Simon Goodman
Claudia Wilm · Darmstadt, DE
Francesc Mitjans · Igualada, ES

Key dates

Filing date	Jul 15, 2010
Grant date	Apr 16, 2013
Priority date	—
Expiry date	Jul 15, 2030

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/70546
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention relates to antibodies that are capable to bind the extracellular domain of integrin. Another object of the invention concerns the use of said antibodies for detecting integrins in archival formalin fixed paraffin embedded (FFPE) tissue. The invention also relates to methods for preparing monoclonal rabbit antibodies, wherein the immunogen is an insect expression culture-derived recombinant extracellular integrin domain, and another method for screening anti-integrin antibodies that discriminate between closest integrin homologues and that are especially suited for immunohistochemistry in FFPE material.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.