Arene connected polyamine macrocyclic derivatives, preparation methods and pharmaceutical uses thereof

US8420626B2 · kind B2 · utility

Assignee

• Beijing Molecule Science and Technology Co., Ltd. · CN

Inventors

• Song Li · Beijing, CN
• Jing Su · Scotch Plains, US
• Yao Liu · Brookline, US
• Junhai Xiao · Beijing, CN
• Lili Wang · Beijing, CN
• Wu Zhong · Beijing, CN
• Zhibing Zheng · Beijing, CN
• Yunde Xie · Beijing, CN
• Xingzhou Li · Beijing, CN
• Guoming Zhao · Beijing, CN
• Xiaokui Wang · Beijing, CN
• Xinbo Zhou · Beijing, CN
• Hongying Liu · Beijing, CN

Key dates

• Filing date: May 30, 2008
• Grant date: Apr 16, 2013
• Expiry date: Jul 1, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.