Pyrimidine compounds and their uses

US8420653B2 · kind B2 · utility

Assignee

• ORCHID CHEMICALS & PHARMACEUTICALS LIMITED · IN

Inventors

• Visweswara Akella Satya Surya Srinivas · Hyderabad, IN
• Ravikumar Tadiparthi · Aurangabad, IN
• Ganapavarapu Veera Raghava Sharma · Visakhapatnam, IN
• Thirunavukkarasu Sappanimuthu · Chennai, IN
• Durairaj Peter Bhakiaraj · Chennai, IN
• Virendra Kachhadia · Chennai, IN
• Kilambi Narasimhan · Chennai, IN
• Sathya Narayana Thara · Chennai, IN
• Sriram Rajagopal · Darsi, IN
• Om Reddy Gaddam · Hyderabad, IN
• Sukunath Narayanan · Chennai, IN
• Venkatesan Parameswaran · Chennai, IN
• Venkatesan Janarthanam · Chennai, IN
• Maruthikumar Narayanam · Chennai, IN
• Sathyanarayana Gadde · Aurangabad, IN
• Uma Ramachandran · Chennai, IN
• Gopalan Balasubramanian · Chennai, IN
• Narayanan Surendran · Ann Arbor, US
• Shridhar Narayanan · Chennai, IN
• Lolaknath Santosh Vishwakarma · Chennai, IN
• Sanjeev Saxena · Chennai, IN

Key dates

• Filing date: Jan 30, 2009
• Grant date: Apr 16, 2013
• Expiry date: Mar 8, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D265/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases.