Method to repair a damaged intervertebral disc through the use of a bioadhesive, thermogelling hydrogel
US8420740B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Aug 21, 2007 |
| Grant date | Apr 16, 2013 |
| Priority date | — |
| Expiry date | Jun 10, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/38
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention is directed to a bioadhesive thermogelling hydrogel composition for repairing and/or augmenting an intervertebral disc. The bioadhesive thermogelling hydrogel composition can be cross linked with the surrounding tissue so as to potentially serve as a nucleus pulposus replacement or augmentation along with serving to repair annular tears or fissure. The bioadhesive thermogelling hydrogel composition may include three main components: a thermal responsive polymer, an amine-containing polymer and a crosslinking component. All three components can be modified and combined in numerous ways to serve the need of the system as long as the amine-containing component is kept separate from the crosslinking component until the components are injected. The incorporation of a two-part crosslinking thermal responsive hydrogel permits smaller amounts of the crosslinking component to be used and enables the crosslinking dialdehyde to be delivered locally into the tissue that will react with the hydrogel. This helps prevent damage to tissues away from the hydrogel.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.