Modular DNA-binding domains and methods of use

US8420782B2 · kind B2 · utility

Inventors

• Ulla Bonas · Bodenwerder, DE
• Jens Boch · Wunstorf, DE
• Sebastian Schornack · Cambridge, GB
• Thomas Lahaye · Usingen, DE

Key dates

• Filing date: Jan 31, 2012
• Grant date: Apr 16, 2013
• Expiry date: Jan 31, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/80
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in a DNA sequence and, to DNA which is modified so that it can be specifically recognized by a polypeptide and to uses of the polypeptide and DNA in specific DNA targeting as well as to methods of modulating expression of target genes in a cell.