Patent · US Active

Suppressor tRNA transcription in vertebrate cells

US8420792B2 · kind B2 · utility

27Cited by

129References

46Claims

0Family size

Assignee

Ambrx, Inc. · US

Inventors

Feng Tian · San Diego, US
Thea Norman · San Diego, US
Stephanie Chu · Simi Valley, US

Key dates

Filing date	Sep 7, 2007
Grant date	Apr 16, 2013
Priority date	—
Expiry date	Sep 21, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P21/02
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.