Patent · US Active

Tetrahydroisoquinolines and intermediates therefor

US8420811B2 · kind B2 · utility

10Cited by

26References

2Claims

0Family size

Assignees

Bristol-Myers Squibb Company · US
ALBANY MOLECULAR RESEARCH, INC. · US

Inventors

Paul Lobben · Lawrenceville, US
Rulin Zhao · Pennington, US
Bei Wang · Hastings-on-Hudson, US
Bang-Chi Chen · Cranbury, US
Shuang Liu · Schenectady, US
Min Hu · Schenectady, US
Yuh-Lin Allen Yang · Baoshan, TW
Matthew Isherwood · Amherst, US
Rasidul Amin · East Greenbush, US
Wenge Cui · Clifton Park, US

Key dates

Filing date	Jun 4, 2009
Grant date	Apr 16, 2013
Priority date	—
Expiry date	Jun 4, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07F5/025
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form. One such intermediate has the following structure:

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.