Patent · US Active

Process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates

US8420812B2 · kind B2 · utility

0Cited by

0References

15Claims

0Family size

Assignee

Sanofi · FR

Inventors

Omar Rkyek · Tangier, MA
Marc Nazare · Idstein, DE
Andreas Lindenschmidt · Bad Soden, DE
Jorge Alonso · Mannheim, DE
Matthias Urmann · Eschborn, DE
Nis Halland · Frankfurt am Main, DE

Key dates

Filing date	Dec 23, 2009
Grant date	Apr 16, 2013
Priority date	—
Expiry date	Dec 2, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonatesThe present invention relates to a process for the regioselective synthesis of compounds of the formula (I),wherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.