Macrocyclic factor VIIa inhibitors useful as anticoagulants

US8420830B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Nicholas R. Wurtz · Pennington, US
• Eldon Scott Priestley · Yardley, US
• Daniel L. Cheney · Ringoes, US
• Peter W. Glunz · Wilmington, US
• Xiaojun Zhang · Hopewell, US
• Brandon Parkhurst · Indianapolis, US
• Vladimir Ladziata · Ewing, US
• Luciano Mueller · Princeton, US

Key dates

• Filing date: Dec 19, 2007
• Grant date: Apr 16, 2013
• Expiry date: Feb 13, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D255/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates generally to novel macrocycles of Formula (I):or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, C, D, L, M, W, Z1, Z2, Z3, Z4, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.