Crystallization of 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol
US8420839B1 · kind B1 · utility
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Key dates
| Filing date | Oct 1, 2012 |
| Grant date | Apr 16, 2013 |
| Priority date | — |
| Expiry date | Oct 1, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of purifying 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol to obtain 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol in crystalline form using precipitation with hexane from ethyl acetate. A method of preparing 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol crystals acceptable for X-ray experiment using precipitation with hexane from benzene by diffusive exchange of the solvents is also described.
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