Dry powder inhaler and system for drug delivery

US8424518B2 · kind B2 · utility

Assignee

• MannKind Corporation · US

Inventors

• Chad C. Smutney · Watertown, US
• P. Spencer Kinsey · Sandy Hook, US
• Carl R. Sahi · Coventry, US
• Benoit Adamo · Mount Kisco, US
• John M. Polidoro · Coventry, US
• Scott McLean · Waterbury, US
• Dennis Overfield · Fairfield, US
• Anthony Bryant · Stratford, US

Key dates

• Filing date: Jun 12, 2009
• Grant date: Apr 23, 2013
• Expiry date: Oct 17, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2206/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.