Patent · US Active

Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7P15-21 and uses thereof

US8425876B2 · kind B2 · utility

10Cited by

8References

12Claims

0Family size

Assignee

The Brigham and Women's Hospital, Inc. · US

Inventors

Markus Frank · Baden-Baden, DE
Mohamed H. Sayegh · Dedham, US

Key dates

Filing date	Feb 9, 2010
Grant date	Apr 23, 2013
Priority date	—
Expiry date	Mar 19, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/34
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.