Detection of sub-cellular compartment localization of a molecule using a reduced affinity enzyme complementation reporter system
US8426138B2 · kind B2 · utility
0Cited by
6References
14Claims
0Family size
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Key dates
| Filing date | Dec 26, 2007 |
| Grant date | Apr 23, 2013 |
| Priority date | — |
| Expiry date | Apr 6, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/726
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods and compositions for detecting the sub-cellular localization of a molecule are provided. Aspects of the invention include detecting translocation of a cell-surface receptor to a sub-cellular compartment, e.g., the endosome, using a reduced affinity enzyme complementation reporter system. Also provided are systems and kits for use in practicing embodiments of the methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.