Multimeric conjugate

US8426357B2 · kind B2 · utility

Assignees

• celares GmbH · DE
• Scil Proteins GmbH · DE

Inventors

• Ralf Kraehmer · Panketal, DE
• Frank Leenders · Berlin, DE
• Erik Fiedler · Halle (Saale), DE
• Thomas Hey · Bad Nauheim, DE
• Ulrike Fiedler · Bodenwerder, DE
• Markus Fiedler · Bodenwerder, DE

Key dates

• Filing date: Feb 11, 2008
• Grant date: Apr 23, 2013
• Expiry date: Dec 28, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/65
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have a longer life time in vivo and an increased avidity compared to the unmodified biologically agent. The present invention is further directed to a pharmaceutical or diagnostic composition containing said conjugate as well as to a method of its production. The invention additionally provides the use of said conjugates for the detection, determination, separation and/or isolation of a specific binding partner and for the diagnosis, prophylaxis and treatment of diseases in which the specific binding partner is directly or indirectly involved.