Inhibition of viral gene expression using small interfering RNA
US8426380B2 · kind B2 · utility
6Cited by
2References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 2, 2011 |
| Grant date | Apr 23, 2013 |
| Priority date | — |
| Expiry date | Mar 2, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/36111
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection. ShRNA and siRNA constructs targetING the internal ribosome entry site (IRES) sequence of HCV are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.