Method of producing FR901228
US8426556B2 · kind B2 · utility
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8References
1Claims
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Inventors
Key dates
| Filing date | May 17, 2012 |
| Grant date | Apr 23, 2013 |
| Priority date | — |
| Expiry date | May 17, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/101
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.