Dendritic cell marker and uses thereof

US8426565B2 · kind B2 · utility

Assignee

• THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH · AU

Inventors

• Mireille Hanna Lahoud · Melbourne, AU
• Anna Irene Proietto · Melbourne, AU
• Irina Caminschi · Melbourne, AU
• Ken Shortman · Queenstown, AU
• Andrew Mark Lew · Melbourne, AU
• Li Wu · Melbourne, AU
• Mark Dexter Wright · Melbourne, AU

Key dates

• Filing date: Aug 29, 2008
• Grant date: Apr 23, 2013
• Expiry date: Sep 7, 2028

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the identification of proteins located on the cell surface of dendritic cells or precursors thereof, particularly antigen presenting dendritic cells. In particular, the present invention relates to compounds such as antibodies that bind these proteins. These compounds can be used to detect and/or enrich a subset of dendritic cells or precursors thereof. These compounds can also be used to target antigens to dendritic cells or precursors thereof to modulate a humoral and/or T cell mediated immune response to an antigen, or used to target cytotoxic agents to dendritic cells or precursors thereof involved in diseased states.